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Functional connectivity in resting-state fMRI: Is linear correlation sufficient?
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SYSNO ASEP 0356655 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Functional connectivity in resting-state fMRI: Is linear correlation sufficient? Tvůrce(i) Hlinka, Jaroslav (UIVT-O) RID, SAI, ORCID
Paluš, Milan (UIVT-O) RID, SAI, ORCID
Vejmelka, Martin (UIVT-O) SAI, RID, ORCID
Mantini, D. (BE)
Corbetta, M. (IT)Zdroj.dok. Neuroimage. - : Elsevier - ISSN 1053-8119
Roč. 54, č. 3 (2011), s. 2218-2225Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova fMRI ; functional connectivity ; Gaussianity ; nonlinearity ; correlation ; mutual information Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEP 7E08027 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z10300504 - UIVT-O (2005-2011) UT WOS 000286302000044 EID SCOPUS 78650180896 DOI 10.1016/j.neuroimage.2010.08.042 Anotace Functional connectivity (FC) analysis is a prominent approach to analyzing fMRI data, especially acquired in resting state. The commonly used linear correlation bears an implicit assumption of Gaussianity of the dependence structure. To assess the suitability of linear correlation and the general potential of nonlinear FC measures, we present a framework for testing and estimating the deviation from Gaussianity by comparing mutual information in the data and its Gaussianized counterpart. We apply this method to 24 sessions of human resting state fMRI. While the group-level tests confirmed non-Gaussianity in the FC, the quantitative assessment revealed that the portion of mutual information neglected by linear correlation is relatively minor - on average only about 5% of the total mutual information. We conclude that for this type of data, practical relevance of nonlinear methods trying to improve over linear correlation is limited by the fact that the data are almost Gaussian. Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2011
Počet záznamů: 1