Počet záznamů: 1
Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning
- 1.
SYSNO ASEP 0355826 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning Tvůrce(i) Kozmiková, Iryna (UMG-J) RID
Smolíková, Jana (UMG-J) RID
Vlček, Čestmír (UMG-J) RID
Kozmik, Zbyněk (UMG-J) RIDZdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 6, č. 2 (2011), e14650Poč.str. 21 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Wnt Bmp ; amphioxus ; axial patterning Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA500520604 GA AV ČR - Akademie věd IAA500520908 GA AV ČR - Akademie věd CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000287036600003 DOI 10.1371/journal.pone.0014650 Anotace Formation of a dorsoventral axis is a key event in the early development of most animal embryos. It is well established that bone morphogenetic proteins (Bmps) and Wnts are key mediators of dorsoventral patterning in vertebrates. In the cephalochordate amphioxus, genes encoding Bmps and transcription factors downstream of Bmp signaling such as Vent are expressed in patterns reminiscent of those of their vertebrate orthologues. We found that Bmp but not canonical Wnt signaling regulates promoters of genes encoding homeodomain proteins AmphiVent1 and AmphiVent2. Our data indicate high evolutionary conservation of a core Bmp-triggered gene regulatory network for dorsoventral patterning in chordates and suggest that co-option of the canonical Wnt signaling pathway for dorsoventral patterning in vertebrates represents one of the innovations through which an increased morphological complexity of vertebrate embryo is achieved. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2011
Počet záznamů: 1