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The structure of invadopodia in a complex 3D environment
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SYSNO ASEP 0355192 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The structure of invadopodia in a complex 3D environment Tvůrce(i) Tolde, O. (CZ)
Rosel, D. (CZ)
Veselý, Pavel (UMG-J)
Folk, P. (CZ)
Brabek, J. (CZ)Zdroj.dok. European Journal of Cell Biology. - : Elsevier - ISSN 0171-9335
Roč. 89, č. 9 (2010), s. 674-680Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova invadopodia ; invasiveness ; SEM Vědní obor RIV EB - Genetika a molekulární biologie CEP LC06061 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000281890900006 DOI 10.1016/j.ejcb.2010.04.003 Anotace Invadopodia and podosomes have been intensively studied because of their involvement in the degradation of extracellular matrix. As both structures have been studied mostly on thin matrices, their commonly reported shapes and characteristics may differ from those in vivo. To assess the morphology of invadopodia in a complex 3D environment, we observed invadopodial formation in cells grown on a dense matrix based on cell-free dermis. We have found that invadopodia differ in morphology when cells grown on the dermis-based matrix and thin substrates are compared. The cells grown on the dermis-based matrix display invadopodia which are formed by a thick protruding base rich in F-actin, phospho-paxillin, phospho-cortactin and phosphotyrosine signal, from which numerous thin filaments protrude into the matrix. The protruding filaments are composed of an F-actin core and are free of phospho-paxillin and phospho-cortactin but capped by phosphotyrosine signal. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2011
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