Počet záznamů: 1

NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours

SYSNO ASEP	0355110
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours
Tvůrce(i)	Indrová, Marie (UMG-J)_RID Šímová, Jana (UMG-J)_RID Bieblová, Jana (UMG-J) Bubeník, Jan (UMG-J) Reiniš, Milan (UMG-J)_RID
Zdroj.dok.	Oncology Reports - ISSN 1021-335X Roč. 25, č. 1 (2011), s. 281-288
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	GR - Řecko
Klíč. slova	MHC class I-deficient tumours ; CD8+, CD4+, NK1.1+cell subpopulations ; interferon gamma
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	IAA500520807 GA AV ČR - Akademie věd
CEZ	AV0Z50520514 - UMG-J (2005-2011)
UT WOS	000286303800038
DOI	10.3892/or_00001072
Anotace	In vivo depletion of CD8+ cells resulted in complete elimination of protective effects after immunization with TC-1 cells (MHC class I+) against the TC-1 tumour challenge. After immunization with TC-1/A9 or MK16 tumour cells (MHC class I-deficient) a remarkable dependence on the presence of NK1.1+ cells was observed, Cytotoxic activity induced by TC-1 cell immunization was abrogated in CD8+ cell-depleted mice and the mice showed similar percentage of IFNgamma-producing cells in CD8+, CD4+ and NK1.1+ subpopulations.. After MK16 or TC-1/A9 cell immunization, NK1.1+ displayed significant reduction of cytotoxicity. The highest proportion of IFNgamma-producing cells was concentrated into the NK1.1+ cells..
Pracoviště	Ústav molekulární genetiky
Kontakt	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Rok sběru	2011

Počet záznamů: 1