Počet záznamů: 1
Alterations in synaptic curvature in the dentate gyrus following induction of long-term potentiation, long-term depression, and treatment with the N-methyl-D-aspartate receptor antagonist CPP
- 1.
SYSNO ASEP 0354978 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Alterations in synaptic curvature in the dentate gyrus following induction of long-term potentiation, long-term depression, and treatment with the N-methyl-D-aspartate receptor antagonist CPP Tvůrce(i) Medvedev, N. I. (GB)
Popov, V. I. (GB)
Dallerac, G. (FR)
Davies, H.A. (GB)
Laroche, S. (FR)
Kraev, I. V. (GB)
Rodríguez Arellano, Jose Julio (UEM-P)
Doyere, V. (FR)
Stewart, M.G. (GB)Zdroj.dok. Neuroscience. - : Elsevier - ISSN 0306-4522
Roč. 171, č. 2 (2010), s. 390-397Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova D synaptic ultrastructure ; hippocampus ; long term potentiation and depression Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000284194000004 DOI 10.1016/j.neuroscience.2010.09.014 Anotace Alterations in curvature of the post synaptic density (PSD) and apposition zone (AZ), are believed to play an important role in determining synaptic efficacy. In the present study we have examined curvature of PSDs and AZs 24 h following homosynaptic long-term potentiation (LTP), and heterosynaptic long-term depression (LTD) in vivo, in awake adult rats.Very large and significant changes in 3-D measurements of AZ and PSD curvature occurred 24 h following both LTP and LTD, with a flattening of the normal concavity of mushroom spine heads and a change to convexity for thin spines. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2011
Počet záznamů: 1