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Catalytic activity of matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma
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SYSNO ASEP 0354940 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Catalytic activity of matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma Tvůrce(i) Chan, K.C. (CN)
Ko, J.M. (CN)
Lung, H.L. (CN)
Sedláček, Radislav (UMG-J) RID
Zhang, Z.F. (CN)
Luo, D.Z. (CN)
Feng, Z.B. (CN)
Chen, S. (CN)
Chen, H. (CN)
Chan, K.W. (CN)
Tsao, S.W. (CN)
Chua, D.T. (CN)
Zabarovsky, E.R. (SE)
Stanbridge, E.J. (US)
Lung, M.L. (CN)Zdroj.dok. International Journal of Cancer. - : Wiley - ISSN 0020-7136
Roč. 129, č. 8 (2011), s. 1826-1837Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova MMP19 ; nasopharyngeal carcinoma ; tumor suppressor gene ; angiogenesis Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000294224300004 DOI 10.1002/ijc.25855 Anotace The association of matrix metalloproteinase-19 (MMP19) in the development of nasopharyngeal carcinoma (NPC) was identified from differential gene profiling, which showed MMP19 was one of the candidate genes down-regulated in the NPC cell lines. In this study, analysis showed MMP19 was down-regulated in all seven NPC cell lines and in 69.7% of primary NPC specimens. Allelic deletion and promoter hypermethylation contribute to MMP19 down-regulation. In the in vivo tumorigenicity assay, only the wild-type, but not mutant, MMP19 transfectants suppress tumor formation in nude mice. In the in vitro colony formation assay, WT MMP19 dramatically reduces colony-forming ability of NPC cell lines. In the tube formation assay secreted WT MMP19, but not mutant MMP19, induces reduction of tube-forming ability in endothelial cells with decreased vascular endothelial growth factor. The anti-angiogenic activity of WT MMP19 is correlated with suppression of tumor formation. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2012
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