Počet záznamů: 1
Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure
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SYSNO ASEP 0353964 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure Tvůrce(i) Rössnerová, Andrea (UEM-P) RID
Špátová, Milada (UEM-P)
Schunck, CH. (DE)
Šrám, Radim (UEM-P) RIDZdroj.dok. Mutagenesis. - : Oxford University Press - ISSN 0267-8357
Roč. 26, č. 1 (2011), s. 169-175Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova automated micronucleus assay ; environmental exposure ; Metasystems Metafer image cytometry system Vědní obor RIV DN - Vliv životního prostředí na zdraví CEP SP/1B3/8/08 GA MŽP - Ministerstvo životního prostředí 1QS500390506 GA AV ČR - Akademie věd CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000285627700025 EID SCOPUS 78650640476 DOI 10.1093/mutage/geq057 Anotace This mini-review presents the current stage of development of the Metasystems Metafer MNScore system for automated image analysis scoring of micronuclei (MN) in human lymphocytes. A new field for application of this method was opened in 2009, when it was used in a biomonitoring study, assessing the effect of exposure to carcinogenic PAHs in ambient air on the frequency of MN in a group of policemen from Prague. The data from further studies are also presented, in which the above mentioned analysis system was used to evaluate the impact of air pollution on MN in bus drivers, asthmatic children, office and laboratory workers. It is concluded that the automated image analysis is a promising tool for improving risk assessment of human populations exposed to environmental or occupational mutagens. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2011
Počet záznamů: 1