Počet záznamů: 1
Therapeutic Targets for Influenza - Perspectives in Drug Development
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SYSNO ASEP 0353675 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Therapeutic Targets for Influenza - Perspectives in Drug Development Tvůrce(i) Majerová, Taťána (UOCHB-X) RID, ORCID
Hoffman, H. (CZ)
Majer, F. (CZ)Celkový počet autorů 3 Zdroj.dok. Collection of Czechoslovak Chemical Communications. - : Ústav organické chemie a biochemie AV ČR, v. v. i. - ISSN 0010-0765
Roč. 75, č. 1 (2010), s. 81-103Poč.str. 23 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova influenza ; drug research ; protein structure ; oligonucleotides Vědní obor RIV CE - Biochemie CEP 1M0508 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000274668100005 DOI 10.1135/cccc2009087 Anotace Since new and dangerous influenza virus strains, such as H5N1 "avian flu" and more recently the swine-origin H1N1 "swine flu", are constantly evolving, the need for effective anti-influenza drugs is pressing. It is becoming clear that the emergence of drug-resistant viruses will be a major potential problem in future efforts to control influenza virus infection. Moreover, development of vaccines against new influenza strains takes several months, and their production capacity is limited. Thus, new classes of anti-influenza drugs are highly sought after. This review focuses mainly on novel strategies, including targeting viral entry into host cells, inhibition of viral transcription and genome replication, and targeting of the NS1 influenza protein. Another approach involves viral RNA silencing by siRNAs or by antisense oligonucleotides. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2011
Počet záznamů: 1