Počet záznamů: 1
IgM-antibody responses of chickens to salivary antigens of Triatoma infestans as early biomarkers for low-level infestation of triatomines
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SYSNO ASEP 0352618 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název IgM-antibody responses of chickens to salivary antigens of Triatoma infestans as early biomarkers for low-level infestation of triatomines Tvůrce(i) Schwarz, Alexandra (BC-A)
Medrano-Mercado, N. (BO)
Billingsley, P. F. (GB)
Schaub, G. A. (DE)
Sternberg, J. M. (GB)Zdroj.dok. International Journal for Parasitology. - : Elsevier - ISSN 0020-7519
Roč. 40, č. 11 (2010), s. 1295-1302Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. AU - Austrálie Klíč. slova antibody response ; Chagas disease ; chickens ; IgM ; recombinant protein ; salivary proteins ; surveillance ; Triatoma infestans Vědní obor RIV EC - Imunologie CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000280936100008 DOI 10.1016/j.ijpara.2010.03.013 Anotace The recombinant form of a highly immunogenic 14.6 kDa protein in Triatoma infestans saliva (rTiSP14.6) is a potential epidemiological marker for the detection of triatomine bug populations using IgG responses in peridomestic chickens. However, the persistence of the IgG response prevents it being of value for several months in areas where triatomine control programmes have been implemented. In this investigation, IgM-antibody reactions to crude salivary antigens or rTiSP14.6 decayed rapidly after exposure of chickens and were measurable for only 18 days after a single challenge with T. infestans. In serial exposure experiments, chickens from low and high exposure groups showed no significant differences in anti-saliva and anti-rTiSP14.6 IgM-antibody titres. Highly immunogenic salivary antigens of 12 and 14 kDa were recognised by all chicken sera. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2011
Počet záznamů: 1