Počet záznamů: 1

Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia

SYSNO ASEP	0351994
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia
Tvůrce(i)	Bohuslavová, Romana (BTO-N)_RID Kolář, František (FGU-C)_{RID, ORCID, SAI} Kuthanová, Lada (BTO-N) Neckář, Jan (FGU-C)_{RID, ORCID} Tichopád, Aleš (BTO-N) Pavlínková, Gabriela (BTO-N)_{RID, ORCID}
Zdroj.dok.	Journal of Applied Physiology. - : American Physiological Society - ISSN 8750-7587 Roč. 109, č. 4 (2010), s. 1195-1202
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	Hypoxia inducible factor 1 alpha ; hypoxia ; gene expression profiling
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	GA301/09/0117 GA ČR - Grantová agentura ČR
CEZ	AV0Z50520701 - BTO-N (2007-2013)
	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000285344900033
DOI	10.1152/japplphysiol.00366.2010
Anotace	Although physiological responses to chronic hypoxia, including pulmonary hypertension and right ventricular hypertrophy, have been well described, the molecular mechanisms involved in cardiopulmonary adaptations are still not fully understood. We hypothesize that adaptive responses to chronic hypoxia are the result of altered transcriptional regulations in the right and left ventricles. Here we report results from the gene expression profiling of adaptive responses in a chronically hypoxic heart. Of 11 analyzed candidate genes, the expression of seven and four genes, respectively, was significantly altered in the right ventricle of hypoxic male and female mice. In the transcriptional profile of the left ventricle, we identified a single expression change in hypoxic males (Vegfa gene). To directly test the role of HIF1, we analyzed the expression profile in Hif1a partially deficient mice exposed to moderate hypoxia
Pracoviště	Biotechnologický ústav
Kontakt	Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700
Rok sběru	2011

Počet záznamů: 1