Počet záznamů: 1
Malignant mesothelioma: biology, diagnosis and therapeutic approaches
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SYSNO ASEP 0351303 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Malignant mesothelioma: biology, diagnosis and therapeutic approaches Tvůrce(i) Tomasetti, M. (IT)
Amati, M. (IT)
Santarelli, L. (IT)
Alleva, R. (IT)
Neužil, Jiří (UMG-J)Zdroj.dok. Current Molecular Pharmacology. - : Bentham Science Publishers - ISSN 1874-4672
Roč. 2, č. 2 (2009), s. 190-206Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. AE - Spojené arabské emiráty Klíč. slova malignant mesothelioma ; biology ; diagnosis and therapeutic approaches Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520514 - UMG-J (2005-2011) DOI 10.2174/1874467210902020190 Anotace Malignant mesothelioma (MM) is an aggressive neoplasm of serosal cavities, which is resistant to conventional therapy, with patient survival from presentation of less than 12 months. MM remains a universally fatal disease of increasing incidence worldwide. Although the main risk factor is asbestos exposure, other factors, Simian virus 40 infection and inheritance of susceptibility genes, likely play a role. Asbestos-related carcinogenic process is primarily based on the interaction between susceptibility (genetic and acquired) and exposure to carcinogenic environmental agents. The long promotion phase observed in MM pathogenesis and the absence of early symptoms both contribute to late diagnosis of the disease. This results in delayed therapeutic intervention of patients, making the outcome of the disease very grim. This review presents recent developments in the pathogenesis, diagnosis and new therapeutic approaches of MM. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2011
Počet záznamů: 1