Počet záznamů: 1
Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats
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SYSNO ASEP 0349311 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats Tvůrce(i) Stofková, A. (CZ)
Železná, Blanka (UOCHB-X) RID, ORCID
Romzová, Marianna (BTO-N)
Uličná, O. (CZ)
Kiss, A. (SK)
Skurlová, M. (CZ)
Jurcovicová, J. (CZ)Celkový počet autorů 7 Zdroj.dok. Mediators of Inflammation. - : Hindawi - ISSN 0962-9351
-, ID 398026 (2010), s. 1-12Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova adjuvant arthritis ; feeding Vědní obor RIV CE - Biochemie CEP GA305/06/0427 GA ČR - Grantová agentura ČR GAP303/10/1368 GA ČR - Grantová agentura ČR CEZ AV0Z40550506 - UOCHB-X (2005-2011) AV0Z50520701 - BTO-N (2007-2013) UT WOS 000283184700001 DOI 10.1155/2010/398026 Anotace We studied the effect of food restriction, overfeeding, and normofeeding on cachexia, inflammatory and metabolic parameters, and insulin sensitivity in chronic adjuvant arthritis (AA) in rats. Food restriction during AA increased circulating ghrelin, corticosterone, decreased leptin, and ameliorated arthrogram score and systemic inflammation compared to normofeeding. Overfeeding worsened arthrogram score and systemic inflammation, and led to lipid accumulation in the liver, but not to alterations of adipokine and ghrelin plasma levels relative to normofeeding. Independently of feeding status, AA induced cachexia, in which modulation of mRNA expressions for appetite-regulating neuropeptides (NPY, AgRP, POMC, CART) in the arcuate nucleus (ARC) does not play a primary role. The overexpression of IL-1beta mRNA in the ARC suggests its role in the mechanisms of impaired energy balance during AA under all feeding conditions. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2011
Počet záznamů: 1