Počet záznamů: 1
The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition
- 1.
SYSNO ASEP 0347271 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition Tvůrce(i) Hada, K. (JP)
Asahina, Masako (BC-A) RID
Hasegawa, H. (JP)
Kanaho, Y. (JP)
Slack, F. J. (US)
Niwa, R. (JP)Zdroj.dok. Developmental Biology. - : Elsevier - ISSN 0012-1606
Roč. 344, č. 2 (2010), s. 1100-1109Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova apl-1 ; Caenorhabditis elegans ; heterochronic gene ; heterochronic gene ; let-7 ; nuclear receptor ; nhr-25 Vědní obor RIV EB - Genetika a molekulární biologie CEP GA204/07/0948 GA ČR - Grantová agentura ČR GD204/09/H058 GA ČR - Grantová agentura ČR CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000280787100049 DOI 10.1016/j.ydbio.2010.05.508 Anotace Precise timing is essential for animal development. Its alteration, known as heterochrony, causes morphogenetic defects. Yet, little is known about the relationship between timing regulation and execution in terms of molecular action in the cell. Nuclear receptors play multiple roles in animal development, and NHR-25, an ancient member of the family, is involved in morphogenesis of various tissues of the worm C. elegans. We demonstrated that NHR-25 genetically interacts with the pathway of heterochronic genes including downstream targets of the let-7 microRNAs. NHR-25 together with the heterochronic genes modulates the timing of tissue-specific gene expression, cell fusion, cell division and cuticle formation. These data present the first example of a nuclear receptor interaction with the heterochrony pathway. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2011
Počet záznamů: 1