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The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies
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SYSNO ASEP 0346788 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies Tvůrce(i) Živný, J. (CZ)
Klener, P. (CZ)
Pytlík, R. (CZ)
Anděra, Ladislav (UMG-J) RIDZdroj.dok. Current Pharmaceutical Design - ISSN 1381-6128
Roč. 16, č. 1 (2010), s. 11-33Poč.str. 23 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova apoptosis ; cancer therapy ; leukemia Vědní obor RIV EB - Genetika a molekulární biologie CEP NS10287 GA MZd - Ministerstvo zdravotnictví 1M0506 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000272773200003 DOI 10.2174/138161210789941883 Anotace Apoptosis is a normal aspect of human physiology ensuring tissue homeostasis. Evasion of endogenous cell death processes, including apoptosis, represents one of the characteristics of cancer. Defects in the physiological mechanisms of apoptosis contribute to the pathological cell expansion and to the development and progression of cancer. Resistance of malignant cells to cancer therapeutic agents may be, in some cases, caused by dysregulation of apoptotic pathways, e.g. BCL2 or IAP overexpression. The understanding of the physiological mechanisms that control apoptosis and the elucidation of apoptotic defects in cancer cells may lead to the development of targeted cancer therapies. Apoptotic pathways, molecules involved in the cross-talk between individual apoptosis pathways and promising new anti-cancer agents, which trigger directly or indirectly apoptosis of hematologic cancer cells, are reviewed in this article. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2011
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