Počet záznamů: 1  

MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells

  1. 1.
    SYSNO ASEP0346783
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevMMP19 is upregulated during melanoma progression and increases invasion of melanoma cells
    Tvůrce(i) Muller, M. (DE)
    Beck, Inken (UMG-J) RID
    Gadesmann, J. (DE)
    Karschuk, N. (DE)
    Paschen, A. (DE)
    Proksch, E. (DE)
    Djonov, V. (CH)
    Reiss, K. (DE)
    Sedláček, Radislav (UMG-J) RID
    Zdroj.dok.Modern Pathology - ISSN 0893-3952
    Roč. 23, č. 4 (2010), s. 511-521
    Poč.str.11 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovamelanoma ; invasion ; matrix metalloproteinase
    Vědní obor RIVEB - Genetika a molekulární biologie
    CEZAV0Z50520514 - UMG-J (2005-2011)
    UT WOS000276197100003
    DOI10.1038/modpathol.2009.183
    AnotaceIn this study, we analysed the expression of MMP19 in the course of melanoma progression. Although MMP19 was absent in melanocytes and melanoma cells of early stages of melanoma development, its expression was strongly upregulated in the neighbouring keratinocytes. In contrast to early stages, MMP19 was upregulated during the vertical growth phase of melanoma and in metastases. The upregulation of MMP19 in melanoma of Clark levels IV and V correlates with that of MMP2 and E-cadherin. Melanoma cell lines with low expression of MMP19 exhibited increased adhesion to various substrates and lower migration in comparison with the cell line with higher expression of MMP19. Moreover, ectopic expression of MMP19 could restore the migratory capacity of melanoma cells with low endogenous level of MMP19. These results suggest that the increase of MMP19 expression hallmarks the progression of cutaneous melanoma and might augment melanoma growth by promoting the invasion of tumour cells.
    PracovištěÚstav molekulární genetiky
    KontaktGabriela Marešová, maresova@img.cas.cz, Tel.: 241 063 217
    Rok sběru2011