Počet záznamů: 1

Numerical studies of the membrane fluorescent dyes dynamics in ground and excited states

SYSNO ASEP	0346415
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Numerical studies of the membrane fluorescent dyes dynamics in ground and excited states
Tvůrce(i)	Barucha-Kraszewska, Justyna (UFCH-W) Kraszewski, S. (FR) Jurkiewicz, Piotr (UFCH-W)_{RID, ORCID} Ramseyer, Ch. (FR) Hof, Martin (UFCH-W)_{RID, ORCID}
Zdroj.dok.	Biochimica Et Biophysica Acta-Biomembranes. - : Elsevier - ISSN 0005-2736 Roč. 1798, č. 9 (2010), s. 1724-1734
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	NL - Nizozemsko
Klíč. slova	molecular dynamics ; fluorescent probe ; membrane
Vědní obor RIV	CF - Fyzikální chemie a teoretická chemie
CEP	LC06063 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	GA203/08/0114 GA ČR - Grantová agentura ČR
CEZ	AV0Z40400503 - UFCH-W (2005-2011)
UT WOS	000280752100010
DOI	10.1016/j.bbamem.2010.05.020
Anotace	Fluorescence methods are widely used in studies of biological and model membranes. The dynamics of membrane fluorescent markers in their ground and excited electronic states and correlations with their molecular surrounding within the fully hydrated phospholipid bilayer are still not well understood. In the present work, Quantum Mechanical (QM) calculations and Molecular Dynamics (MD) simulations are used to characterize location and interactions of two membrane polarity probes (Prodan; 6-propionyl-2-dimethylaminonaphthalene and its derivative Laurdan; 2-dimethylamino-6-lauroylnaphthalene) with the dioleoylphosphatidylcholine (DOPC) lipid bilayer model. MD simulations with fluorophores in ground and excited states are found to be a useful tool to analyze the fluorescent dye dynamics and their immediate vicinity. The results of QM calculations and MD simulations are in excellent agreement with available experimental data.
Pracoviště	Ústav fyzikální chemie J.Heyrovského
Kontakt	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Rok sběru	2011

Počet záznamů: 1