Počet záznamů: 1
Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units
- 1.
SYSNO ASEP 0346349 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units Tvůrce(i) Navrátil, Tomáš (UFCH-W) RID, ORCID
Kohlíková, E. (CZ)
Petr, M. (CZ)
Pelclová, D. (CZ)
Heyrovský, Michael (UFCH-W) RID
Přistoupilová, K. (CZ)Zdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 59, č. 3 (2010), s. 431-442Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova creatine ; creatinine ; folates ; homocysteine Vědní obor RIV CF - Fyzikální chemie a teoretická chemie CEP IAA400400806 GA AV ČR - Akademie věd CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000280363700016 Anotace The administration of creatine (5 g/day for one month) to 11 young active sportsmen affected their urinary excretion of creatine, creatinine, and thiodiglycolic acid (TDGA) as well as blood levels of homocysteine, vitamin B-12 and folates. The probands were divided into four groups, according to the amount of creatine found in urine, and of folates and vitamin B-12 determined in blood. The changes of folates and vitamin B-12 were mutually reciprocal. Each group utilized CR as donor of one- and two-carbon (1C and 2C) units by means of homocysteine (HoCySH), folates, and vitamin B-12, in different metabolic pathways. In 10 men the creatine administration was accompanied by an increase of HoCySH level in blood, while in the last man, with accidentally discovered hyperhomocysteinemia, the HoCySH level dropped by 50 %. Differences between initial and terminal TDGA levels indicate that creatine affects equilibria of redox processes. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2011
Počet záznamů: 1