Počet záznamů: 1
Micelle-like nanoparticles of block copolymer poly(ethylene oxide)-block-poly(methacrylic acid) incorporating fluorescently substituted metallacarboranes designed as HIV protease inhibitor interaction probes
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SYSNO ASEP 0346345 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Micelle-like nanoparticles of block copolymer poly(ethylene oxide)-block-poly(methacrylic acid) incorporating fluorescently substituted metallacarboranes designed as HIV protease inhibitor interaction probes Tvůrce(i) Uchman, M. (CZ)
Cígler, Petr (UOCHB-X) RID, ORCID
Grüner, Bohumír (UACH-T) RID, SAI, ORCID
Procházka, K. (CZ)
Matějíček, P. (CZ)Celkový počet autorů 5 Zdroj.dok. Journal of Colloid and Interface Science. - : Elsevier - ISSN 0021-9797
Roč. 348, č. 1 (2010), s. 129-136Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova metallacarboranes ; micelles ; drug delivery Vědní obor RIV CC - Organická chemie CEP LC523 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy IAAX00320901 GA AV ČR - Akademie věd CEZ AV0Z40550506 - UOCHB-X (2005-2011) AV0Z40320502 - UACH-T (2005-2011) UT WOS 000278924600016 DOI 10.1016/j.jcis.2010.04.037 Anotace We prepared nanoparticles differing in morphology from double-hydrophilic block copolymer poly(ethylene oxide)-block-poly(methacrylic acid), PEO–PMA, and two types of fluorescein–[3-cobalt(III) bis(1,2-dicarbollide)] conjugates, GB176 and GB179, in alkaline buffer. GB176 molecule consists of fluorescein attached to the metallacarborane anion. In GB179 molecule, the fluorescein moiety connects two metallacarborane anions. The self-assembly is based on the unusual interaction of metallacarborane clusters with PEO blocks which form insoluble micellar cores. The GB176 containing nanoparticles are loose and irregular, while the GB179 ones are rigid and spherical. The micelles were studied by static and dynamic light scattering, fluorometry and atomic force microscopy. Since the metallacarborane conjugates act as potent inhibitors of HIV protease, the presented system is important from the point of view of drug delivery. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2011
Počet záznamů: 1