Počet záznamů: 1
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP
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SYSNO ASEP 0346304 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP Tvůrce(i) Hájek, Miroslav (UOCHB-X) RID, ORCID
Cvilink, Viktor (UOCHB-X)
Votruba, Ivan (UOCHB-X) RID
Holý, Antonín (UOCHB-X)
Mertlíková-Kaiserová, Helena (UOCHB-X) RID, ORCIDCelkový počet autorů 5 Zdroj.dok. European Journal of Pharmacology. - : Elsevier - ISSN 0014-2999
Roč. 643, č. 1 (2010), s. 6-12Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova acyclic nucleoside phosphonates ; PMEG ; PMEDAP ; telomere length ; telomerase inhibition Vědní obor RIV CC - Organická chemie CEP 1M0508 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy 1QS400550501 GA AV ČR - Akademie věd CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000280627700002 DOI 10.1016/j.ejphar.2010.06.006 Anotace We have previously shown that PMEG diphosphate and PMEDAP diphosphate inhibit the enzymatic activity of human telomerase in a cell-free assay. Here, we investigated the ability of PMEG and PMEDAP to induce telomere shortening and telomerase inhibition in two T-cell leukemia cell lines. Both PMEDAP and PMEG induced telomere shortening in CCRF-CEM cells after 9 weeks of exposure while the effect of the compounds on telomere length in MOLT-4 cells was the opposite. No correlation between telomerase activity and telomere length was found. Both compounds also down-regulated the expression of hTERT and c-myc mRNA in both cell lines. In conclusion, PMEDAP and PMEG are able to modulate telomere length in leukemic cells and this effect is cell-type specific. It is neither due to telomerase inhibition nor impairment of hTERT expression and it is likely to be telomerase-independent. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2011
Počet záznamů: 1