Počet záznamů: 1

Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells

SYSNO ASEP	0345683
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells
Tvůrce(i)	Jensen, T.J. (US) Novák, Petr (BC-A)_{RID, ORCID} Wnek, S.M. (US) Gandolfi, A.J. (US) Futscher, B. W. (US)
Celkový počet autorů	5
Zdroj.dok.	Toxicology and Applied Pharmacology. - : Elsevier - ISSN 0041-008X Roč. 241, č. 2 (2009), s. 221-229
Poč.str.	9 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	DNA methylation ; Epigenetic ; Arsenic
Vědní obor RIV	EB - Genetika a molekulární biologie
CEZ	AV0Z50510513 - UMBR-M, BC-A (2005-2011)
UT WOS	000271712600011
DOI	10.1016/j.taap.2009.08.019
Anotace	Aberrant DNA methylation participates in carcinogenesis and is a molecular hallmark of a tumor cell. We used a model of arsenical-induced malignant transformation of immortalized human urothelial cells and DNA methylation microarrays to examine the extent and temporal nature of changes in DNA methylation that occur during the transition from immortal to malignantly transformed. Our data presented herein suggest that during arsenical-induced malignant transformation, aberrant DNA methylation occurs non-randomly, progresses gradually at hundreds of gene promoters, and alters expression of the associated gene, and these changes are coincident with the acquisition of malignant properties, such as anchorage independent growth and tumor formation in immunocompromised mice.
Pracoviště	Biologické centrum (od r. 2006)
Kontakt	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Rok sběru	2011

Počet záznamů: 1