Počet záznamů: 1
High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro
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SYSNO ASEP 0345018 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro Tvůrce(i) Jiruška, P. (GB)
Csicsvari, J. (GB)
Powell, A.V. (GB)
Fox, J.E. (GB)
Chang, W.C. (GB)
Vreugdenhil, M. (GB)
Li, X. (GB)
Paluš, Milan (UIVT-O) RID, SAI, ORCID
Bujan, A.F. (GB)
Dearden, R.W. (GB)
Jefferys, J. G. R. (GB)Zdroj.dok. Journal of Neuroscience. - : Society for Neuroscience - ISSN 0270-6474
Roč. 30, č. 16 (2010), s. 5690-5701Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova mammalian hippocampus invitro ; temporal-lobe epilepsy ; nonsynaptic epileptogenesis ; spatiotemporal dynamics ; after-discharges ; pyramidal cells ; oscillations ; rat ; calcium ; slice Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEZ AV0Z10300504 - UIVT-O (2005-2011) UT WOS 000276923700021 EID SCOPUS 77951609782 DOI 10.1523/JNEUROSCI.0535-10.2010 Anotace How seizures start is a major question in epilepsy research. We demonstrate the existence of a preictal state characterized by the progressive and global increase in neuronal activity associated with a widespread buildup of low-amplitude high-frequency activity (HFA) and reduction in system complexity. Transition to seizure is characterized by a rapid expansion and fusion of the neuronal populations responsible for HFA, associated with a progressive slowing of HFA, leading to a single, massive, hypersynchronous cluster generating the high-amplitude low-frequency activity of the seizure. Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2011
Počet záznamů: 1