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Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy
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SYSNO ASEP 0343927 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy Tvůrce(i) Lammers, T. (DE)
Šubr, Vladimír (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RID
Hennink, W. E. (NL)
Storm, G. (NL)
Kiessling, F. (DE)Zdroj.dok. Nano Today. - : ELSEVIER SCI LTD - ISSN 1748-0132
Roč. 5, č. 3 (2010), s. 197-212Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova nanomedicines ; drug targeting ; polymer Vědní obor RIV EB - Genetika a molekulární biologie CEP 1M0505 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000279753800009 DOI 10.1016/j.nantod.2010.05.001 Anotace Nanomedicine systems aim to improve the biodistribution and the target site accumulation of systemically applied (chemo-) therapeutics. By increasing drug localization at the pathological site, and by reducing its accumulation in healthy organs and tissues, the efficacy of the intervention can often be increased, while its toxicity can be attenuated. Using HPMA copolymers as a model macromolecular nanomedicine system, and several selected examples of recently published proof-of-principle reports, we here show that besides for standard drug delivery purposes, polymeric nanomedicines can also be employed for image-guided drug delivery, as well as for tumor-targeted combination therapy. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2011
Počet záznamů: 1