Počet záznamů: 1
Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study
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SYSNO ASEP 0343468 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study Tvůrce(i) Vrajová, M. (CZ)
Šťastný, František (FGU-C)
Horáček, J. (CZ)
Lochman, J. (CZ)
Šerý, O. (CZ)
Peková, S. (CZ)
Klaschka, Jan (UIVT-O) RID, SAI, ORCID
Höschl, C. (CZ)Zdroj.dok. Neurochemical Research. - : Springer - ISSN 0364-3190
Roč. 35, č. 7 (2010), s. 994-1002Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova schizophrenia ; hippocampus ; GluN1 subunit of NMDA receptor ; splice variants ; laterality Vědní obor RIV FL - Psychiatrie, sexuologie CEZ AV0Z50110509 - FGU-C (2005-2011) AV0Z10300504 - UIVT-O (2005-2011) UT WOS 000278411000005 EID SCOPUS 77953231677 DOI 10.1007/s11064-010-0145-z Anotace There is accumulating evidence that disturbances in N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (eight isoforms altogether) as well as the mRNA individual isoforms in the postmortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. Our results suggest that NMDA-R hypofunction in schizophrenia might be selectively dependent on the dysregulation of GluN1 subunit expression, which exhibits a somewhat different expression in the left/right hippocampus of psychotic patients. Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2011
Počet záznamů: 1