Počet záznamů: 1
Remodelling of living bone induced by dynamic loading and drug delivery—Numerical modelling and clinical treatment
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SYSNO ASEP 0343142 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Remodelling of living bone induced by dynamic loading and drug delivery—Numerical modelling and clinical treatment Tvůrce(i) Maršík, František (UT-L) RID
Klika, Václav (UT-L) RID
Chlup, Hynek (UT-L)Zdroj.dok. Mathematics and Computers in Simulation. - : Elsevier - ISSN 0378-4754
Roč. 80, č. 6 (2010), s. 1278-1288Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova bone remodelling ; chemical kinetics ; biochemical model Vědní obor RIV BJ - Termodynamika CEP GA106/03/1073 GA ČR - Grantová agentura ČR GA106/08/0557 GA ČR - Grantová agentura ČR CEZ AV0Z20760514 - UT-L (2005-2011) UT WOS 000276380400024 DOI 10.1016/j.matcom.2009.02.014 Anotace The biomechanical remodelling process is well formulated for bones and is divided into three stages: (1) bone resorption based on the osteoclast activity, (2) bone deposition based on the osteoblast activity and (3) bone growth control established on RANK/RANKL/OPG pathway-RANKL/OPG balance. The main driving force of remodelling process is a dynamic loading (cyclic compression and expansion, e.g. walking or running), which strongly influences the rate of chemical reactions. The evolution from the omogeneous density distribution to the corticalis and cancellous bone formation is shown. An inevitable influence of a dynamic mechanical loading and osteoprotegerin (OPG) concentration is demonstrated. Pracoviště Ústav termomechaniky Kontakt Marie Kajprová, kajprova@it.cas.cz, Tel.: 266 053 154 ; Jana Lahovská, jaja@it.cas.cz, Tel.: 266 053 823 Rok sběru 2011
Počet záznamů: 1