Počet záznamů: 1

Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all?

SYSNO ASEP	0342950
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all?
Tvůrce(i)	Kořený, Luděk (BC-A)_RID Lukeš, Julius (BC-A)_{RID, ORCID} Oborník, Miroslav (BC-A)_{RID, ORCID}
Zdroj.dok.	International Journal for Parasitology. - : Elsevier - ISSN 0020-7519 Roč. 40, č. 2 (2010), s. 149-156
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	AU - Austrálie
Klíč. slova	haem synthesis ; Kinetoplastida ; evolution ; horizontal gene transfer ; bacterial endosymbiont
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	GA206/08/1423 GA ČR - Grantová agentura ČR
	GD206/09/H026 GA ČR - Grantová agentura ČR
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000274447900002
DOI	10.1016/j.ijpara.2009.11.007
Anotace	Kinetoplastid flagellates represent an interesting group of species, as some of them lost the complete pathway of haem synthesis while others possess only the last 3 biosynthetic steps. We decided to supplement a Current view on the phylogeny of these important pathogens with the expected state of haem synthesis in representative species. We propose a scenario in which the ancestor of all trypanosomatids was completely deficient of the synthesis of haem. In trypanosomatids other than members of the genus Trypanosoma, the pathway was partially rescued by genes encoding enzymes for the last three steps, Supposedly obtained by horizontal transfer from a gamma-proteobacterium. This event preceded the diversification of the non-Trypanosoma trypanosomatids. Later, some flagellates acquired a beta-proteobacterial endosymbiont which supplied them with haem precursors. The medically important trypanosomes have remained fully deficient of haem synthesis and obtain this compound from the host.
Pracoviště	Biologické centrum (od r. 2006)
Kontakt	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Rok sběru	2011

Počet záznamů: 1