Počet záznamů: 1

The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei

SYSNO ASEP	0342884
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei
Tvůrce(i)	Hashimi, Hassan (BC-A)_{RID, ORCID} Benkovičová, V. (SK) Čermáková, P. (SK) Lai, De Hua (BC-A) Horváth, A. (SK) Lukeš, Julius (BC-A)_{RID, ORCID}
Zdroj.dok.	International Journal for Parasitology. - : Elsevier - ISSN 0020-7519 Roč. 40, č. 1 (2010), s. 45-54
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	AU - Austrálie
Klíč. slova	RNA editing ; ATP synthase ; mitochondrion ; Trypanosoma ; respiratory complex ; membrane potential
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	GA204/06/1558 GA ČR - Grantová agentura ČR
	IAA500960705 GA AV ČR - Akademie věd
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000274104300005
DOI	10.1016/j.ijpara.2009.07.005
Anotace	Taking advantage of the different phenotypes between RNA interference knock-down cell lines in which the expression of proteins involved in mtRNA metabolism and editing can be silenced, we provide support for the view that ATP6 is encoded in the mt genome of Trypanosoma species and that it is incorporated into complex V. The reduction of the F1FO oligomer of complex V coincides with the accumulation of the F, moiety in ATP6-lacking cells, which also appear to lack the F-O ATP9 multimeric ring. The oligomycin sensitivity of ATPase activity of complex V in ATP6-lacking cells is reduced, reflecting the insensitivity of the Dk and Ak cells to this drug. In addition, the F, moiety of complex V appears to exist as a dimer in steady state conditions and contains the ATP4 subunit traditionally assigned to the F-O sub-complex.
Pracoviště	Biologické centrum (od r. 2006)
Kontakt	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Rok sběru	2011

Počet záznamů: 1