Počet záznamů: 1

Proteome Mining of Human Follicular Fluid Reveals a Crucial Role of Complement Cascade and Key Biological Pathways in Women Undergoing in Vitro Fertilization

SYSNO ASEP	0341837
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Proteome Mining of Human Follicular Fluid Reveals a Crucial Role of Complement Cascade and Key Biological Pathways in Women Undergoing in Vitro Fertilization
Tvůrce(i)	Jarkovská, Karla (UZFG-Y)_RID Martinková, Jiřina (UZFG-Y) Lišková, Lucie (UZFG-Y) Halada, Petr (MBU-M)_{RID, ORCID} Moos, J. (CZ) Rezábek, K. (CZ) Gadher, S. J. (CH) Kovářová, Hana (UZFG-Y)_{RID, ORCID}
Zdroj.dok.	Journal of Proteome Research. - : American Chemical Society - ISSN 1535-3893 Roč. 9, č. 3 (2010), s. 1289-1301
Poč.str.	13 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	Human follicular fluid ; plasma ; assisted reproduction
Vědní obor RIV	FK - Gynekologie a porodnictví
CEP	NS9781 GA MZd - Ministerstvo zdravotnictví
	1QS500450568 GA AV ČR - Akademie věd
CEZ	AV0Z50450515 - UZFG-Y (2005-2011)
	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000275088100012
DOI	10.1021/pr900802u
Anotace	The primary aim of this study was to search for specific differences in protein composition of human follicular fluid (HFF) and plasma in order to identify proteins that accumulate or are absent in HFF. Depletion of abundant proteins combined with multidimensional protein fractionation allowed the study of middle- and lower-abundance proteins. Paired comparison study examining HFF with plasma/serum from women undergoing successful IVF revealed important differences in the protein composition which may improve our knowledge of the follicular microenvironment and its biological role. This study showed involvement of innate immune function of complement cascade in HFF Complement inhibition and the presence of C-terminal fragment of perlecan suggested possible links to angiogenesis which is a vital process in folliculogenesis and placental development. Differences in proteins associated with blood coagulation were also found in the follicular milieu.
Pracoviště	Ústav živočišné fyziologie a genetiky
Kontakt	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Rok sběru	2011

Počet záznamů: 1