Počet záznamů: 1
Modulation of AMPA excitatory postsynaptic currents in the spinal cord dorsal horn neurons by insulin
- 1.
SYSNO ASEP 0341812 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Modulation of AMPA excitatory postsynaptic currents in the spinal cord dorsal horn neurons by insulin Tvůrce(i) Špicarová, Diana (FGU-C) RID, ORCID
Paleček, Jiří (FGU-C) RID, ORCIDZdroj.dok. Neuroscience. - : Elsevier - ISSN 0306-4522
Roč. 166, č. 1 (2010), s. 305-311Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova pain ; synaptic modulation ; insulin Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEP GA305/06/1115 GA ČR - Grantová agentura ČR GA305/09/1228 GA ČR - Grantová agentura ČR LC554 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000274507500031 DOI 10.1016/j.neuroscience.2009.12.007 Anotace Glutamate AMPA receptors are critical for sensory transmission at the spinal cord dorsal horn (DH). Plasma membrane AMPA receptor endocytosis that can be induced by insulin may underlie long term modulation of synaptic transmission. In this work the effect of insulin application on fast excitatory postsynaptic currents (EPSCs) mediated by AMPA receptors evoked in DH neurons was evaluated. Acute spinal cord slices from 6 to 10 day old mice were used to record EPSCs evoked in visually identified superficial DH neurons by dorsal root primary afferent stimulation. AMPA EPSCs could be evoked in all of the tested neurons. In 75% of the neurons the size of the AMPA EPSCs was reduced to 62.1% and to 68.9% of the control values when 0.5 or 10 _M insulin was applied.Our results suggest a possible role of the insulin pathway in modulation of sensory and nociceptive synaptic transmission in the spinal cord. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2011
Počet záznamů: 1