Počet záznamů: 1
High-molecular-weight polymers containing biodegradable disulfide bonds: synthesis and in vitro verification of intracellular degradation
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SYSNO ASEP 0338553 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název High-molecular-weight polymers containing biodegradable disulfide bonds: synthesis and in vitro verification of intracellular degradation Tvůrce(i) Etrych, Tomáš (UMCH-V) RID, ORCID
Kovář, Lubomír (MBU-M)
Šubr, Vladimír (UMCH-V) RID, ORCID
Braunová, Alena (UMCH-V) RID
Pechar, Michal (UMCH-V) RID, ORCID
Chytil, Petr (UMCH-V) RID, ORCID
Říhová, Blanka (MBU-M) RID
Ulbrich, Karel (UMCH-V) RIDZdroj.dok. Journal of Bioactive and Compatible Polymers. - : Sage - ISSN 0883-9115
Roč. 25, č. 1 (2010), s. 5-26Poč.str. 22 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova water-soluble polymers ; reductive degradation ; HPMA copolymers Vědní obor RIV CD - Makromolekulární chemie CEP IAA400500806 GA AV ČR - Akademie věd KAN200200651 GA AV ČR - Akademie věd CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z50200510 - MBU-M (2005-2011) UT WOS 000274186900001 DOI 10.1177/0883911509353485 Anotace The synthesis, physico-chemical behavior, and in vitro intracellular degradation of new biodegradable graft, diblock or multiblock polymer carriers that were designed to deliver bioactive compounds by passive tumor targeting were investigated. In all three carrier systems, the single polymers were linked via biodegradable disulfide bonds forming the graft, diblock or multiblock polymers. Here, degradation of the polymers in model buffer solutions mimicking intracellular environment as well as after incubation with EL4 T-cell lymphoma cancer cells were investigated. In both cases, degradation resulted in polymer fragments of molecular weight below the renal threshold. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2010
Počet záznamů: 1