Počet záznamů: 1

High-molecular-weight polymers containing biodegradable disulfide bonds: synthesis and in vitro verification of intracellular degradation

  1. 1.
    SYSNO ASEP0338553
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    NázevHigh-molecular-weight polymers containing biodegradable disulfide bonds: synthesis and in vitro verification of intracellular degradation
    Tvůrce(i)Etrych, Tomáš (UMCH-V) - Kovář, Lubomír (MBU-M) - Šubr, Vladimír (UMCH-V) - Braunová, Alena (UMCH-V) - Pechar, Michal (UMCH-V) - Chytil, Petr (UMCH-V) - Říhová, Blanka (MBU-M) - Ulbrich, Karel (UMCH-V)
    Rozsah stran5 - 26
    Zdroj.dok.Journal of Bioactive and Compatible Polymers. - : SAGE PUBLICATIONS LTD - ISSN 0883-9115
    Poč.str.22 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovawater-soluble polymers ; reductive degradation ; HPMA copolymers
    Vědní obor RIVCD - Makromolekulární chemie
    CEPIAA400500806 GA AV ČR - Akademie věd
    KAN200200651 GA AV ČR - Akademie věd
    CEZAV0Z40500505 - UMCH-V (2005-2011)
    AV0Z50200510 - MBU-M (2005-2011)
    UTISI000274186900001
    DOI10.1177/0883911509353485
    AnotaceThe synthesis, physico-chemical behavior, and in vitro intracellular degradation of new biodegradable graft, diblock or multiblock polymer carriers that were designed to deliver bioactive compounds by passive tumor targeting were investigated. In all three carrier systems, the single polymers were linked via biodegradable disulfide bonds forming the graft, diblock or multiblock polymers. Here, degradation of the polymers in model buffer solutions mimicking intracellular environment as well as after incubation with EL4 T-cell lymphoma cancer cells were investigated. In both cases, degradation resulted in polymer fragments of molecular weight below the renal threshold.
    PracovištěÚstav makromolekulární chemie
    KontaktEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Rok sběru2010