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The DNA-damage response in human biology and disease
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SYSNO ASEP 0337838 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The DNA-damage response in human biology and disease Tvůrce(i) Jackson, S.P. (GB)
Bártek, Jiří (UMG-J) RIDZdroj.dok. Nature. - : Palgrave Macmillan - ISSN 0028-0836
Roč. 461, č. 7267 (2009), s. 1071-1078Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova DNA damage response ; human disease ; cancer Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000270987600034 DOI https://doi.org/10.1038/nature08467 Anotace The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular events, are biologically significant because they prevent diverse human diseases. Our improving understanding of DNA-damage responses is providing new avenues for disease management. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2010
Počet záznamů: 1