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Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water
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SYSNO ASEP 0335375 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water Tvůrce(i) Gál, Miroslav (UFCH-W)
Hromadová, Magdaléna (UFCH-W) RID, ORCID, SAI
Pospíšil, Lubomír (UFCH-W) RID, ORCID
Híveš, J. (SK)
Sokolová, Romana (UFCH-W) RID, ORCID, SAI
Kolivoška, Viliam (UFCH-W) RID, ORCID
Kocábová, Jana (UFCH-W) RIDZdroj.dok. Bioelectrochemistry. - : Elsevier - ISSN 1567-5394
Roč. 78, č. 2 (2010), s. 118-123Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova etanidazole ; radiosensitizer ; electron transfer ; voltammetry Vědní obor RIV CG - Elektrochemie CEP GP203/09/P502 GA ČR - Grantová agentura ČR CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000277218900004 DOI 10.1016/j.bioelechem.2009.08.008 Anotace Cytotoxic properties of radiosensitizers are due to the fact that, in the metabolic pathway, these compounds undergo one-electron reduction to generate radical anions. In this study we focused our interest on the electrochemical transfer of the first electron on radiosensitizer Etanidazole (ETN) and, consequently, on the ETN radical-anion formation in the buffered aqueous media. ETN was electrochemically treated in the broad pH range at various scan rates. Three reduction peaks and one oxidation peak were found. At strong alkaline pH the four-electron reduction peak was separated into one-electron and three-electron reductions. Under these conditions the standard rate constant k0 for the redox couple ETN − NO2 + e− right arrow over left arrow ETN − NO2•− was calculated. Moreover, the value of a so called E71 potential that accounts for the energy necessary to transfer the first electron to an electroactive group at pH = 7 in aqueous medium to form a radical anion was also determined. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2011
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