Počet záznamů: 1

Tick-borne encephalitis virus infection of cultured mouse macrophages

SYSNO ASEP	0334900
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Tick-borne encephalitis virus infection of cultured mouse macrophages
Tvůrce(i)	Ahantarig, A. (TH) Růžek, Daniel (BC-A)_{RID, ORCID} Vancová, Marie (BC-A)_{RID, ORCID} Janowitz, A. (GB) Šťastná, Hana (BC-A) Tesařová, Martina (BC-A)_ORCID Grubhoffer, Libor (BC-A)_{RID, ORCID}
Zdroj.dok.	Intervirology - ISSN 0300-5526 Roč. 52, č. 5 (2009), s. 283-290
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	SZ - Svazijsko
Klíč. slova	tick-borne encephalitis ; macrophages ; electron microscopy
Vědní obor RIV	GJ - Choroby a škůdci zvířat, veterinární medicína
CEP	GA524/06/1479 GA ČR - Grantová agentura ČR
	LC06009 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000269788600008
DOI	10.1159/000235741
Anotace	The interactions of tick-borne encephalitis virus (TBEV) with mouse macrophages were studied at electron microscopic level. The macrophages were sensitive to infection with TBEV strain Hypr (a highly neuroinvasive and neurovirulent strain for laboratory mice). However, these macrophage cells remained morphologically inactivated. Viral particles were located mainly in the ER. No virus production was observed in cells infected with the attenuated, non-neuroinvasive TBEV strain 263. In this case, the infection led to a clear morphological activation of the macrophages. The virus replication process in mouse macrophage cells might be different from that in other mammalian cell lines. Moreover, different TBEV strains exhibited a different interaction with the host macrophages. The inability of strain 263 to replicate in mouse macrophages as the first site of significant viral replication in vivo could be associated with the inability of this strain to establish a serious infection in mice.
Pracoviště	Biologické centrum (od r. 2006)
Kontakt	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Rok sběru	2010

Počet záznamů: 1