Počet záznamů: 1
Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility
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SYSNO ASEP 0334121 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility Tvůrce(i) Lipoldová, Marie (UMG-J) RID
Havelková, Helena (UMG-J)
Badalová, Jana (UMG-J)
Vojtíšková, Jarmila (UMG-J)
Quan, L. (US)
Krulová, Magdalena (UMG-J)
Sohrabi, Yahya (UMG-J)
Stassen, A. P. M. (NL)
Demant, P. (US)Celkový počet autorů 9 Zdroj.dok. Cancer Immunology and Immunotherapy. - : Springer - ISSN 0340-7004
Roč. 59, č. 2 (2010), s. 203-213Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova Tumor susceptibility ; Genetic control of interferon gamma production ; Lymphocyte infiltration of tumors Vědní obor RIV EB - Genetika a molekulární biologie CEP LC06009 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy IAA500520606 GA AV ČR - Akademie věd GD310/08/H077 GA ČR - Grantová agentura ČR CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000271748600003 DOI 10.1007/s00262-009-0739-y Anotace Previously we mapped four loci (Lynf1-Lynf4) controlling lymphocyte infiltration of mouse lung tumors. These loci do not encode any of the molecules that are involved in traffic of lymphocytes. Here we report a genetic relationship between these loci and the control of production of IFNgamma in allogeneic mixed lymphocyte cultures (MLC). We found that IFNgamma production by lymphocytes of O20/A mice is lower than by OcB-9/Dem (both H2 ( pz )) stimulated in MLC by irradiated splenocytes of C57BL/10SnPh (H2 ( b )) or BALB/cHeA (H2 ( d )) mice, or by ConA. IFNgamma production in MLCs of F2 (O20 x OcB-9) mice stimulated by irradiated C57BL/10 MLC revealed four IFNgamma-controlling loci (Cypr4-Cypr7), each of which is closely linked with one of the four Lynf loci and with a cluster of susceptibility genes for different tumors. This suggests that inherited differences in certain lymphocyte responses may modify their propensity to infiltrate tumors and their capacity to affect tumor growth. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2010
Počet záznamů: 1