Počet záznamů: 1
Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti
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SYSNO ASEP 0334103 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti Tvůrce(i) Drahota, J. (CZ)
Lipoldová, Marie (UMG-J) RID
Volf, P. (CZ)
Rohoušová, Iva (UMG-J)Celkový počet autorů 4 Zdroj.dok. Parasite immunology. - : Wiley - ISSN 0141-9838
Roč. 31, č. 12 (2009), s. 766-770Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova anti-saliva IgG ; cellular response ; Phlebotomus sergenti Vědní obor RIV EB - Genetika a molekulární biologie CEP LC06009 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000271469600005 DOI 10.1111/j.1365-3024.2009.01155.x Anotace Sand flies transmit parasites of genus Leishmania, the causative agents of leishmaniases. Experimental hosts repeatedly exposed to sand fly saliva can control Leishmania infection. Cell-mediated anti-saliva immune response is most likely responsible for this protective effect; however, there is no study concerning its antigenic specificity. In this study, splenocytes from mice exposed to Phlebotomus sergenti bites were challenged ex vivo with saliva from three different sand flies. Mice bitten by P. sergenti had higher proliferation to homologous antigen than splenocytes from naive mice. Splenocytes from P. sergenti bitten mice as well as anti-P. sergenti antibodies partially cross-reacted with P. papatasi saliva. In contrast, no crossreactivity was found with P. arabicus saliva. Our data indicate that both cellular and humoral immunity react in a species-specific manner and the unique transmission-blocking vaccine would be required for each vector – Leishmania combination. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2010
Počet záznamů: 1