Počet záznamů: 1
DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism
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SYSNO ASEP 0334067 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism Tvůrce(i) Zíková, Martina (UMG-J) RID
Corlett, Alicia (UMG-J)
Bendová, Zdeňka (FGU-C)
Pajer, Petr (UMG-J)
Bartůněk, Petr (UMG-J) RIDCelkový počet autorů 5 Zdroj.dok. Molecular Endocrinology - ISSN 0888-8809
Roč. 23, č. 4 (2009), s. 520-528Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova thyroid hormone receptor ; cholesterol metabolism ; sterol-sensing domain Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA500520705 GA AV ČR - Akademie věd CEZ AV0Z50520514 - UMG-J (2005-2011) AV0Z50110509 - FGU-C (2005-2011) UT WOS 000264707000010 DOI 10.1210/me.2008-0271 Anotace In the body the brain is the most cholesterol-rich organ. Despite this, remarkably little is known about the mechanisms in the brain that regulate cholesterol homeostasis. Thyroid hormone receptors, activated in response to thyroid hormone (T3), are known to modulate the level of serum cholesterol via complex regulatory pathways. By screening for T3-regulated genes we identified Disp3, a sterol-sensing protein that is related to the Dispatched family of proteins. Using the model of hyperthyroidism in vivo we observed modulation of the Disp3 expression. DISP3 localizes within the endoplasmic reticulum and was further found to co-localize with cholesterol. Ectopic expression of DISP3 resulted in elevated cholesterol levels combined with an altered cholesterol distribution. Taken together, we propose that DISP3 represents a new molecular link between thyroid hormone and cholesterol metabolism in the brain. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2010
Počet záznamů: 1