Počet záznamů: 1

Targed neural stem cell differentiation and related cell based therapy in spinal cord injury

SYSNO ASEP	0330776
Druh ASEP	C - Konferenční příspěvek (mezinárodní konf.)
Zařazení RIV	D - Článek ve sborníku
Název	Targed neural stem cell differentiation and related cell based therapy in spinal cord injury
Tvůrce(i)	Skalníková, Helena (UZFG-Y)_{RID, ORCID} Vodička, Petr (UZFG-Y)_ORCID Halada, Petr (MBU-M)_{RID, ORCID} Maršala, M. (US) Motlík, Jan (UZFG-Y)_{RID, ORCID} Gadher, S. J. (CH) Kovářová, Hana (UZFG-Y)_{RID, ORCID}
Zdroj.dok.	3rd Central and Eastern Proteomics Conference, 2009. - Budapest : Hungarian proteomic society, 2009 - ISBN 978-963-9319-99-8
Rozsah stran	s. 81-81
Poč.str.	1 s.
Akce	3rd Central and Eastern Proteomics Conference, 2009
Datum konání	06.10.2009-09.10.2009
Místo konání	Budapešť
Země	HU - Maďarsko
Typ akce	EUR
Jazyk dok.	eng - angličtina
Země vyd.	HU - Maďarsko
Klíč. slova	stem cells ; cell therapy ; spinal cord injury
Vědní obor RIV	FH - Neurologie, neurochirurgie, neurovědy
CEP	1M0538 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ	AV0Z50450515 - UZFG-Y (2005-2011)
	AV0Z50200510 - MBU-M (2005-2011)
Anotace	Transplantation of stem cells represents a unique approach to treat spinal trauma. To follow in vivo traumatic changes, the signalling proteins were studied in the rat spinal cord transsection. 80th motoneurons and sensory neurons were subjected to analysis. Computer modeling of protein changes indicates that downregulated proteins belong to oxidative stress response as well as cellular fate and organisation. Increase of proteins involved in genome maintenance was observed in ventral horns. Only marginal changes were found in the dorsal root ganglia. To characterise mechanisms governing differentiation we combined the porcine neural stem cells in vitro differentiation and complementary proteomic analyses. The stem cells exhibited high levels of GRK2 and several members of FAS pathway. Typical for differentiated neural cells were enhanced integrin, PDGF and MAP kinase signalling and heme-oxygenase 2. Characterisation of changes related to cell differentiation helps to define suitab
Pracoviště	Ústav živočišné fyziologie a genetiky
Kontakt	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Rok sběru	2010

Počet záznamů: 1