Počet záznamů: 1
Estrogenic and androgenic activity of PCBs, their chlorinated metabolites and other endocrine disruptors estimated with two in vitro yeast assays
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SYSNO ASEP 0330344 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Estrogenic and androgenic activity of PCBs, their chlorinated metabolites and other endocrine disruptors estimated with two in vitro yeast assays Tvůrce(i) Svobodová, Kateřina (MBU-M) RID
Plačková, Martina (MBU-M) RID
Novotná, V. (CZ)
Cajthaml, Tomáš (MBU-M) RID, ORCIDZdroj.dok. Science of the Total Environment. - : Elsevier - ISSN 0048-9697
Roč. 407, č. 22 (2009), s. 5921-5925Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova endocrine distruptors ; yeast bioassays ; triclosan Vědní obor RIV EE - Mikrobiologie, virologie CEP LC06066 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy 2B06156 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA525/09/1058 GA ČR - Grantová agentura ČR CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000271338600016 DOI 10.1016/j.scitotenv.2009.08.011 Anotace Investigations of environmental pollution by endocrine disrupting chemicals are now in progress. Up to now, several in vitro bioassays have been developed for evaluation of the endocrine disruptive activity; however, there is still a lack of comparative studies of their sensitivity. In this work comparison of the estrogen screening assay based on b-galactosidase expression and a bioluminiscent estrogen screen revealed differences in the sensitivity and specificity of the two tests. With the b-galactosidase screen a slight estrogen-like activity of Delor 103, a commercial mixture of PCB congeners, and a fungicide triclosan was measured whereas no activity was detected using the bioluminescent assay. A bioluminescent androgen test negated previously suggested androgenic potential of triclosan Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2010
Počet záznamů: 1