Počet záznamů: 1

Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives

SYSNO ASEP	0328721
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives
Překlad názvu	Syntéza, charakterizace a biologická aktivita substituovaných derivátů 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurinu
Tvůrce(i)	Szüčová, Lucie (UEB-Q)_{RID, ORCID} Spíchal, Lukáš (UEB-Q)_{RID, ORCID} Doležal, Karel (UEB-Q)_{RID, ORCID} Zatloukal, Marek (UEB-Q)_ORCID Greplová, Jarmila (UEB-Q)_ORCID Galuszka, P. (CZ) Kryštof, Vladimír (UEB-Q)_{RID, ORCID} Voller, Jiří (UEB-Q)_{RID, ORCID} Popa, Igor (UEB-Q) Massino, F.J. (US) Jorgensen, J.E. (US) Strnad, Miroslav (UEB-Q)_{RID, ORCID}
Zdroj.dok.	Bioorganic & Medicinal Chemistry. - : Elsevier - ISSN 0968-0896 Roč. 17, č. 5 (2009), s. 1938-1947
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	Cytokinins ; Antisenescence ; Receptor
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	1M06030 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	GA522/09/1576 GA ČR - Grantová agentura ČR
	GA522/08/0920 GA ČR - Grantová agentura ČR
CEZ	AV0Z50380511 - UEB-Q (2005-2011)
UT WOS	000264067900020
DOI	10.1016/j.bmc.2009.01.041
Anotace	In an attempt to improve specific biological functions of cytokinins routinely used in plant micropropagation, thirty-three 6-benzylamino-9-tetrahydropyran-2-ylpurine (THPP) and 9-tetrahydrofuran-2-ylpurine (THFP) derivatives were prepared. The new derivatives were prepared by condensation of 6-chloropurine with 3,4-dihydro-2H-pyran or 2,3-dihydrofuran and then by the condensation with the corresponding benzylamines. The prepared compounds were characterized by elemental analyses, TLC, HPLC, melting point determinations, CI+ MS and 1H NMR spectroscopy. The cytokinin activity of all the prepared derivatives was assessed in three classical cytokinin bioassays as well as receptor assay. Subsequently, the susceptibility of several new derivatives to enzyme degradation was studied. To provide a practical perspective, , the pH stability and cytotoxicity of the prepared compounds against human diploid fibroblasts and the human cancer cell lines K-562 and MCF-7 was also assayed.
Pracoviště	Ústav experimentální botaniky
Kontakt	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Rok sběru	2010

Počet záznamů: 1