Počet záznamů: 1
Cbf11 and Cbf12, the fission yeast CSL proteins, play opposing roles in cell adhesion and coordination of cell and nuclear division
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SYSNO ASEP 0328355 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cbf11 and Cbf12, the fission yeast CSL proteins, play opposing roles in cell adhesion and coordination of cell and nuclear division Tvůrce(i) Převorovský, M. (CZ)
Groušl, Tomáš (MBU-M) RID, ORCID
Staňurová, J. (CZ)
Ryneš, J. (CZ)
Nellen, W. (DE)
Půta, F. (CZ)
Folk, P. (CZ)Zdroj.dok. Experimental Cell Research. - : Elsevier - ISSN 0014-4827
Roč. 315, č. 8 (2009), s. 1533-1547Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova csl family ; fission yeast ; adhesion Vědní obor RIV EE - Mikrobiologie, virologie CEP GD204/03/H066 GA ČR - Grantová agentura ČR CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000265438300017 DOI 10.1016/j.yexcr.2008.12.001 Anotace The CSL (CBF1/RBP-J/Suppressor of Hairless/LAG-1) family is comprised of transcription factors essential for metazoan development, mostly due to their involvement in the Notch receptor signaling pathway. Recently, we identified two novel classes of CSL genes in the genomes of several fungal species, organisms lacking the Notch pathway. In this study, we characterized experimentally cbf11plus and cbf12plus, the two CSL genes of Schizosaccharomyces pombe, in order to elucidate the CSL function in fungi. We provide evidence supporting their identity as genuine CSL genes. Both cbf11plus and cbf12plus are non-essential, they have distinct expression profiles and code for nuclear proteins with transcription activation potential. Significantly, we demonstrated that Cbf11 recognizes specifically the canonical CSL response element GTGA/GGAA in vitro Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2010
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