Počet záznamů: 1
Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity - role of individual hydroxyl groups
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SYSNO ASEP 0328277 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity - role of individual hydroxyl groups Překlad názvu Molekulární mechanismus antiradikálové aktivity silybinu a 2,3-dehydrosilybinu – úloha jednotlivých hydroxylových skupin Tvůrce(i) Gažák, Radek (MBU-M) RID, ORCID
Sedmera, Petr (MBU-M)
Vrbacký, Marek (FGU-C) RID, ORCID
Vostálová, J. (CZ)
Drahota, Zdeněk (FGU-C) RID, ORCID
Marhol, Petr (MBU-M) RID
Walterová, D. (CZ)
Křen, Vladimír (MBU-M) RID, ORCIDZdroj.dok. Free Radical Biology and Medicine. - : Elsevier - ISSN 0891-5849
Roč. 46, č. 6 (2009), s. 745-758Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova silybin ; silymarin ; dehydrosilybin Vědní obor RIV EE - Mikrobiologie, virologie CEP KJB400200701 GA AV ČR - Akademie věd GA303/06/1261 GA ČR - Grantová agentura ČR GA303/08/0658 GA ČR - Grantová agentura ČR CEZ AV0Z50200510 - MBU-M (2005-2011) AV0Z50110509 - FGU-C (2005-2011) UT WOS 000264061400006 DOI 10.1016/j.freeradbiomed.2008.11.016 Anotace The flavonolignans silybin (1) and 2,3-dehydrosilybin (2) are important natural compounds with multiple biological activities operating at various cell levels. Many of these effects are connected with their radical-scavenging activities. The molecular mechanisms of the antioxidant activity of these compounds and even the functional groups responsible for this activity are not yet well known. Their mechanism can be inferred from the structures of the dimeric products obtained from radical-mediated reactions of selectively methylated derivatives of 1 and 2. The radical oxidation of 1 methylated at 7-OH and 2 methylated at both 3-OH and 7-OH yields C–C and C–O dimers that enable the molecular mechanism of their E-ring interaction with radicals to be elucidated and shows the importance of the 20-OH group in this respect. The pivotal role of the 3-OH group in the radical-scavenging activity of 2 was confirmed through the formation of another type of dimer from its selectively methylated derivative Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2010
Počet záznamů: 1