Počet záznamů: 1
Extremely high MHC class I variation in a population of a long-distance migrant, the Scarlet Rosefinch (Carpodacus erythrinus)
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SYSNO ASEP 0325113 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Extremely high MHC class I variation in a population of a long-distance migrant, the Scarlet Rosefinch (Carpodacus erythrinus) Tvůrce(i) Promerová, Marta (UBO-W)
Albrecht, Tomáš (UBO-W) RID, SAI, ORCID
Bryja, Josef (UBO-W) RID, SAI, ORCIDZdroj.dok. Immunogenetics. - : Springer - ISSN 0093-7711
Roč. 61, č. 6 (2009), s. 451-461Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova MHC class I ; scarlet rosefinch ; positive selection ; recombination Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA600930608 GA AV ČR - Akademie věd GA206/06/0851 GA ČR - Grantová agentura ČR LC06073 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z60930519 - UBO-W (2005-2011) UT WOS 000266822700004 EID SCOPUS 67349255313 DOI 10.1007/s00251-009-0375-x Anotace We describe the structure and diversity of exon 3 of MHC class I in the Scarlet Rosefinch (Carpodacus erythrinus). Using SSCP, we identified 82 different variants in a population in the Czech Republic. This is the highest MHC class I variation observed in birds. We have not found support for "minimal essential" MHC in this species since individuals exhibited between 3 to 9 different exon 3 sequences, indicating that there may be at least 5 amplified class I genes. By cloning, we obtained and analysed 29 exon sequences and found that all of them could be translated into potentially functional proteins. We found that strong positive selection is acting mainly, but not only, on previously described antigen binding sites. Also, our results indicate that recombination has played an important role in generating diversity of these genes in the Scarlet Rosefinch; we discuss the significance of this genetic diversity in light of the life history traits of this species. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2010
Počet záznamů: 1