Počet záznamů: 1  

Absence of spermatozoal CD46 protein expression and associated rapid acrosome reaction rate in striped field mice (Apodemus agrarius)

  1. 1.
    SYSNO ASEP0324020
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevAbsence of spermatozoal CD46 protein expression and associated rapid acrosome reaction rate in striped field mice (Apodemus agrarius)
    Překlad názvuAbsence exprese spermatozoálního CD46 proteinu je spojena s rychlou akrozomální reakcí u myšice temnopásé (Apodemus agrarius)
    Tvůrce(i) Clift, L. E. (GB)
    Andrlíková, P. (CZ)
    Frolíková, M. (CZ)
    Stopka, P. (CZ)
    Bryja, Josef (UBO-W) RID, SAI, ORCID
    Flanagan, B. F. (GB)
    Johnson, P. M. (GB)
    Dvořáková-Hortová, K. (CZ)
    Zdroj.dok.Reproductive Biology and Endocrinology - ISSN 1477-7827
    Roč. 7, č. 29 (2009), s. 1-9
    Poč.str.9 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovasperm competition ; acrosome reaction ; mating system
    Vědní obor RIVEG - Zoologie
    CEZAV0Z60930519 - UBO-W (2005-2011)
    UT WOS000266491100001
    EID SCOPUS65549159123
    DOI10.1186/1477-7827-7-29
    AnotaceIn rodents, the cell surface complement regulatory protein CD46 is expressed solely on the spermatozoal acrosome membrane. Ablation of the CD46 gene is associated with a faster acrosome reaction. Sperm from three Apodemus species fail to express CD46 protein and exhibit a more rapid acrosome reaction rate than house mice (Mus). Here, we demonstrate that highly promiscuous species A. agrarius transcribe two unique alternatively spliced testicular CD46 mRNA transcripts, which differ from those described previously in other Apodemus species. In addition, A. agrarius CD46 transcripts have an extended AU-rich 3'-untranslated region (UTR) and a truncated 5'-UTR, resulting in failure to express spermatozoal CD46 protein. We show that A. agrarius has a significantly faster spontaneous acrosome reaction rate than A. sylvaticus and Mus. This provides a strategy to increase competitive sperm advantage for individuals, leading to faster fertilisation in this highly promiscuous genus.
    PracovištěÚstav biologie obratlovců
    KontaktHana Slabáková, slabakova@brno.cas.cz, Tel.: 543 422 524
    Rok sběru2009