Alternative Muscle Club. - Leeds : University of Leeds, 2008
S. 36-36
Poč.str.
1 s.
Akce
Alternative Muscle Club /26th/
Datum konání
23.07.2008-25.07.2008
Místo konání
Leeds
Země
GB - Velká Británie
Typ akce
WRD
Jazyk dok.
eng - angličtina
Země vyd.
GB - Velká Británie
Klíč. slova
nuclear mysion
Vědní obor RIV
EB - Genetika a molekulární biologie
CEP
GA204/07/1592 GA ČR - Grantová agentura ČR
LC545 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ
AV0Z50520514 - UMG-J (2005-2011)
Anotace
The research is focused on the function of a nuclear isoform of myosin molecular motor - nuclear myosin I (NM1). This nuclear motor was shown to be involved in transcription, chromatin remodelling and repositioning of transcriptionaly activated regions in the nucleoplasm. NM1 differs from its cytoplasmic variant myosin IC by a unique N-terminal extension of unknown function. We are interested in the structure of the motor domain of NM1 and the relation to the N-terminal domain as it could elucidate the specific properties of the molecule that allow it to perform its nuclear roles.
