Počet záznamů: 1
Complexation and biodistribution study of 111In and 90Y complexes of bifunctional phosphinic acid analogs of H4dota
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SYSNO ASEP 0319937 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Complexation and biodistribution study of 111In and 90Y complexes of bifunctional phosphinic acid analogs of H4dota Překlad názvu Komplexační a biodistribuční studie komplexů 111In a 90Y s bifunkčními H4dota analogy kyseliny fosforné Tvůrce(i) Forsterová, Michaela (UJF-V)
Petřík, M. (CZ)
Lázničková, A. (CZ)
Lázníček, M. (CZ)Zdroj.dok. Applied Radiation and Isotopes. - : Elsevier - ISSN 0969-8043
Roč. 67, č. 1 (2009), s. 21-29Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Biodistribution ; Cyclen derivatives ; DOTA Vědní obor RIV FR - Farmakologie a lékárnická chemie CEP 1QS100480501 GA AV ČR - Akademie věd CEZ AV0Z10480505 - UJF-V (2005-2011) UT WOS 000261858700005 DOI 10.1016/j.apradiso.2008.08.013 Anotace In this study, the complexation rates of two new phosphinate H4dota analogs, H5do3apPrA and H4do3apABn, and H4dota itself were compared under identical conditions. The biodistribution of their 111In and 90Y complexes in healthy rats was also studied. Unlike the observation obtained under “chemical“ conditions where differences between the ligands were observed no such differences in complexation rates were found under radiochemical conditions. The ligands bind the radiometals similarly to H4dota. So, “chemical“ formation kinetic data should be transferred in to radiochemical conditions only with high care and “radiochemical“ complexation experiments should be run as part of standard in vitro studies with new ligands considered as potential radiopharmaceuticals. Pharmacokinetic studies in rats showed similar distribution characteristics for both phosphinate H4dota analogs radiolabelled with 111In and 90Y when compared with that of the 111In–H4dota complex. Pracoviště Ústav jaderné fyziky Kontakt Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Rok sběru 2009
Počet záznamů: 1