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CD133-positive cells are resistant to TRAIL due to up-regulation of FLIP
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SYSNO ASEP 0313828 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název CD133-positive cells are resistant to TRAIL due to up-regulation of FLIP Překlad názvu CD133-pozitivní buňky jsou rezistentní k TRAIL díky zvýšené expresi FLIP Tvůrce(i) Zobalová, Renata (BTO-N) RID
McDermott, L. (AU)
Stantic, M. (AU)
Prokopová, Kateřina (BTO-N) ORCID
Dong, L.-F. (AU)
Neužil, Jiří (BTO-N) RIDZdroj.dok. Biochemical and Biophysical Research Communications. - : Elsevier - ISSN 0006-291X
Roč. 373, č. 4 (2008), s. 567-571Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Cancer stem cells ; apoptosis ; resistance to apoptosis induction Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA500520702 GA AV ČR - Akademie věd CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000258208500021 DOI 10.1016/j.bbrc.2008.06.073 Anotace Recent research shows that cancer stem cells (CSCs) are relatively resistant to apoptosis induction. We studied the effect of the immunological apoptogen TRAIL on Jurkat cells enriched in the CD133-positive population. CD133 high Jurkat cells were more resistant to apoptosis than their CD133 low counterparts, and showed higher level of expression of FLIP, an inhibitor of death receptor-mediated apoptosis. Breast cancer MCF7 cells showed high level of expression CD133 in the unseparated culture, with accompanying high level of FLIP. Down-regulation of FLIP by siRNA resulted in sensitisation of the cells to TRAIL, as documented by more robust apoptosis. We conclude that high expression of FLIP is at least one of the reasons for resistance of CSCs to apoptosis induced by the death ligand TRAIL Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2009
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