Počet záznamů: 1
LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147
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SYSNO ASEP 0307370 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147 Překlad názvu LFA-1-zprostředkovaná adheze leukocytů je regulována interakcemi CD43 s LFA-1 a CD147 Tvůrce(i) Khunkaewla, P. (AT)
Schiller, H.B. (AT)
Paster, W. (AT)
Leksa, V. (SK)
Čermák, Lukáš (UMG-J) ORCID
Anděra, Ladislav (UMG-J) RID
Hořejší, Václav (UMG-J) RID
Stockinger, H. (AT)Zdroj.dok. Molecular Immunology. - : Elsevier - ISSN 0161-5890
Roč. 45, č. 6 (2008), s. 1703-1711Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova leukocyte adhesion and aggregation ; monoclonal antibodies ; receptor signaling Vědní obor RIV EB - Genetika a molekulární biologie CEP 1M0506 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000254181800017 Anotace Activity of LFA-1 (CD11a/CD18) must be tightly controlled at onset of cellular immunity. Sialoglycoprotein CD43 can affect LFA-1-mediated cell adhesion in anti- or pro-adhesive manner. Using Y2H screen and coimmunoprecipitation we identified and characterized physical and functional association of CD43 with 2 novel partners, LFA-1 and CD147. Monoclonal antibodies to both CD43 and CD147 induced homotypic cell aggregation and adhesion of Jurkat T cells and U937 myeloid cells as well as dynamic co-capping of LFA-1 together with CD43 and CD147 to cell contact zones. Cotransfection of CD43 interfered with CD147-induced cell adhesion and aggregation, and siRNA-mediated knock down of CD43 in human T cells led to enhanced LFA-1 activation induced via CD147 and T cell antigen receptor. Triggering CD43 and underlying signaling pathways thus seems to enhance LFA-1 adhesiveness. CD43 also negatively regulates LFA-1 induction via other receptors by dynamic interaction with either LFA-1 or CD147. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2009
Počet záznamů: 1