Počet záznamů: 1

Tumour-inhibitory and antimetastatic effects of IL-2 in mice carrying MHC class I- tumours of HPV16 origin

SYSNO ASEP	0191662
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Ostatní články
Název	Tumour-inhibitory and antimetastatic effects of IL-2 in mice carrying MHC class I- tumours of HPV16 origin
Tvůrce(i)	Indrová, Marie (UMG-J)_RID Bubeník, Jan (UMG-J) Mikyšková, Romana (UMG-J)_RID Vonka, V. (CZ) Šmahel, M. (CZ) Žák, R. (CZ) Šímová, Jana (UMG-J)_RID Bieblová, Jana (UMG-J) Mendoza, Luis (UMG-J) Jandlová, Táňa (UMG-J)
Zdroj.dok.	International Journal of Oncology. - : Spandidos Publications - ISSN 1019-6439 Roč. 2002, č. 20 (2002), s. 643-646
Poč.str.	4 s.
Jazyk dok.	eng - angličtina
Země vyd.	GR - Řecko
Klíč. slova	HPV16, IL-2 ; tumour vaccines ; gene therapy
Vědní obor RIV	EB - Genetika a molekulární biologie
CEZ	AV0Z5052915 - UMG-J
Anotace	Oncogenic, moderately immunogenic, MHC class I- and class II-, B7(-), MK16/l/III ABC (MK16) cells were previously established by co-transfection of HPV16 E6/E7 and activated H-ras oncogene DNA into C57BL/6 kidney cells. Subcutaneous transplantation of these cells produced progressively growing local neoplasms which metastasized spontaneously to lungs and lymph nodes. The MK16 cells were implanted into syngeneic mice and used to examine whether the tumour lacking the signal molecules required for the induction of and sensitivity to T cell immunity is susceptible to local IL-2 treatment and IL-2 gene therapy. Peritumoural administration of human rIL-2 or murine IL-2 gene-modified MK16 tumour vaccine inhibited growth of subcutaneous MK16 tumour transplants and reduced the number of their lung metastases. These results indicate that experimental tumours which are MHC class I- and mimick in this respect a high proportion of human HPV16-associated carcinomas are suitable for IL-2 treatment.
Pracoviště	Ústav molekulární genetiky
Kontakt	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Rok sběru	2004

Počet záznamů: 1