Protein SmD1 je nezbytný pro biogenezi spliced leader RNA
Tvůrce(i)
Zeiner, G. M. (US) Foldynová, Silvie (PAU-O) Sturm, N. R. (US) Lukeš, Julius (PAU-O) Campbell, D. A. (US)
Zdroj.dok.
Eukaryotic Cell
- ISSN 1535-9778
Roč. 3, č. 1 (2004), s. 241-244
Poč.str.
4 s.
Jazyk dok.
eng - angličtina
Země vyd.
US - Spojené státy americké
Klíč. slova
Kinetoplastida ; Trypanosoma ; spliced leader RNA
Vědní obor RIV
EB - Genetika a molekulární biologie
CEZ
AV0Z6022909 - PAU-O, BC-A
Anotace
The Sm-binding site of the kinetoplastid spliced leader RNA has been implicated in accurate spliced leader RNA maturation and trans-splicing competence. In Trypanosoma brucei, RNA interference-mediated knockdown of SmD1 caused defects in spliced leader RNA maturation, displaying aberrant 3'-end formation, partial formation of cap 4, and overaccumulation in the cytoplasm; U28 pseudouridylation was unaffected
