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Density-related changes in selection pattern for major histocompatibility complex genes in fluctuating populations of voles
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SYSNO ASEP 0090913 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Density-related changes in selection pattern for major histocompatibility complex genes in fluctuating populations of voles Překlad názvu Typ selekce působící na geny hlavního histokompatibilního systému u hrabošů závisí na hustotě Tvůrce(i) Bryja, Josef (UBO-W) RID, SAI, ORCID
Charbonnel, N. (FR)
Berthier, K. (FR)
Galan, M. (FR)
Cosson, J.-F. (FR)Zdroj.dok. Molecular Ecology. - : Wiley - ISSN 0962-1083
Roč. 16, č. 23 (2007), s. 5084-5097Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Arvicola terrestris ; balancing selection ; local adaptation ; MHC ; population cycles Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA600930608 GA AV ČR - Akademie věd Další zdroj rámcový projekt EK CEZ AV0Z60930519 - UBO-W (2005-2011) UT WOS 000251205200018 EID SCOPUS 36348998788 DOI 10.1111/j.1365-294X.2007.03584.x Anotace We investigated whether two MHC class II genes (DQA1, DRB) were subjected to contemporary selection during increases in the density of fossorial water vole (Arvicola terrestris) populations. In the low-abundance phase, when populations were geographically isolated, both overall differentiation and isolation-by-distance were more marked for MHC genes than for neutral markers. Model-based simulations identified DQA1 as an outlier (i.e. under selection) in a single population, suggesting the action of local selection in fragmented populations. The differences between MHC and neutral markers gradually disappeared with increasing effective migration between sites. In the high-abundance year, DQA1 displayed significantly lower levels of overall differentiation than the neutral markers. Spatial and temporal fluctuations in parasite pressure and locus-specific selection are probably the most plausible mechanisms underlying the observed changes in selection pattern during the demographic cycle. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2008
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