Počet záznamů: 1

A role for adenosine deaminase in Drosophila larval development

SYSNO ASEP	0030136
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Ostatní články
Název	A role for adenosine deaminase in Drosophila larval development
Překlad názvu	Pro pochopení funkce drozofilích adenozin deamináz v organismu, je nutná podrobná analýza mutanta ADGF-A
Tvůrce(i)	Doležal, T. (CZ) Doleželová, Eva (ENTU-I) Žurovec, Michal (ENTU-I) Bryant, P. J. (US)
Zdroj.dok.	PLOS Biology. - : Public Library of Science - ISSN 1544-9173 Roč. 3, č. 7 (2005), s. 1213-1224
Poč.str.	12 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	Drosophila
Vědní obor RIV	ED - Fyziologie
CEP	GA204/04/1205 GA ČR - Grantová agentura ČR
	IAA5007107 GA AV ČR - Akademie věd
CEZ	AV0Z50070508 - ENTU-I, BC-A (2005-2011)
Anotace	Adenosine deaminase is an enzyme present in all organisms that catalyzes the irreversible deamination of adenosine and deoxyadenosine. ADA deficiency in humans causes severe combined immunodeficiency. We have established a Drosophila model to study the effects of altered adenosine levels in vivo by genetic elimination of adenosine deaminase-related growth factor-A, which has ADA activity and is expressed in the gut and hematopoietic organ. The elevated level of adenosine in the hemolymph due to lack of ADGF-A leads to apparently inconsistent phenotypic effects: precocious metamorphic changes including differentiation of macrophage-like cells and fat body disintegration on one hand, and delay of development with block of pupariation on the other. The block of pupariation appears to involve signaling through the adenosine receptor (AdoR), but fat body disintegration, seems to be independent of the AdoR. The existence of such an independent mechanism has also been suggested in mammals.
Pracoviště	Entomologický ústav (do r. 2005)
Kontakt	Helena Musilová, musilova@entu.cas.cz, Tel.: 387 775 216
Rok sběru	2006

Počet záznamů: 1